A study investigated the adjustment shock of first-year residents in China using latent profile analysis.[1] The research included 574 valid questionnaires from residents of four national training centers in Hubei Province, collected from September 2023 to August 2024.[2] The total score for adaptation shock was 83.43 ± 18.25 points, indicating a moderate level of shock, with the highest score in the knowledge and skills dimension (3.59 ± 0.74).[1] The analysis identified three groups of residents: a group with low psychological and sociocultural shock (13.41%), a group with high physical and knowledge shock (27.01%), and a group with moderate shock (59.58%).[2] Higher scores on professional cognition, commitment, and expectations were associated with lower levels of adjustment shock.[2] However, a strong sense of professional values was associated with higher adjustment shock, which may be due to a gap between ideal and reality.[2] The study recommends layered interventions targeting individual groups of residents and specialized support for Master of Medicine candidates.[2]