Clinical characteristics and outcomes in 50 children with autoimmune hepatitis: a retrospective study from a single centre in China

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Source: Frontiers Medicine

Original: https://www.frontiersin.org/articles/10.3389/fmed.2025.1733006...

Published: 2026-01-12T00:00:00Z

The study examined 50 children with autoimmune hepatitis (AIH) in a Beijing center from 2015–2025, with a mean age of 9.2 years.[3] At diagnosis, 48% of children had cirrhosis, 22% liver failure, and 20% decompensated cirrhosis.[3] Children with type 2 AIH were younger and had higher levels of liver enzymes (alanine aminotransferase and aspartate aminotransferase) compared to type 1.[3] All patients received immunosuppressive therapy—either a glucocorticoid alone or in combination with azathioprine or mycophenolate mofetil.[3] 85.4% of patients with a native liver survived, while there was no statistically significant difference in prognosis between individual types of treatment.[3] Lower serum albumin levels and the presence of decompensated cirrhosis at diagnosis have been identified as independent factors influencing the risk of death or the need for liver transplantation.[3]