The yellow fever vaccine was among the first successful human vaccines and has been used for more than 80 years. It is produced by cultivation in eggs, which limits its production capacity and prevents rapid spread during disease outbreaks. The global stockpile of vaccine for the response to outbreaks is 6 million doses. In 2016, during the epidemic in Angola and the Democratic Republic of the Congo, the global supply of the vaccine was almost exhausted twice. The comment emphasizes that the minimum partial dose of yellow fever vaccine does not apply to infants.