The study designed and validated a spherical nasal vestibular stent for the treatment of nasal obstruction based on changes in the structure of the nasal vestibule. Ninety-nine patients with nasal obstruction confirmed by anterior rhinoscopy were enrolled and underwent CT scans before and after dilation until symptoms had almost resolved. The three-dimensional reconstruction showed the correlation of changes in the volume of the nasal vestibule with the values of the VAS score for nasal obstruction according to the Spearman analysis. The nitinol mesh stent was designed based on 3D models and computational fluid dynamics parameters adapted to the anatomy of the nasal vestibule. In a single-arm clinical trial in 31 patients, the stent significantly reduced nasal resistance (p < 0.05), increased nasal volume and valve area (p < 0.001), and reduced NOSE scores (p < 0.001), assessed by acoustic rhinometry and rhinomanometry. Most patients tolerated the stent well, with mild side effects such as dryness and pain. The study describes it as a promising non-surgical intervention with minimal risk.