Brief, factual summary in Slovak: The new issue of JAMA contains several important topics. The first is navigation contrary to vaccination recommendations. Additional topics include the efficacy and safety of the oral PCSK9 inhibitor enlicitide in adults with heterozygous familial hypercholesterolemia, as well as a review of metabolic liver damage associated with steatosis in adults. In addition, it also deals with the impact of climate change on allergic rhinitis and sinusitis. The journal provides physicians worldwide with essential medical information and a unique forum for discussions that shape the future of medical practice and public health.