Primary palmoplantar pustulosis is a rare skin disease characterized by the appearance of sterile pustules on the palms and soles. An article in the New England Journal of Medicine (Volume 394, Issue 3, January 15, 2026) describes the clinical presentation, diagnosis, and treatment of this condition. Symptoms include red, scaly lesions with pus-filled blisters that recur and cause pain and limitation of movement. The disease mainly affects women aged 40–60 years, with an incidence of approximately 0.05% in the Caucasian population. Diagnosis is established by clinical examination and exclusion of infections or psoriasis. The main treatment is topical corticosteroids and TNF inhibitors, with remissions in 60–70% of patients after 6 months of therapy. The study emphasizes differentiation from seborrheic dermatitis and palmoplantar psoriasis. Complications include secondary bacterial infections in 15% of cases.