The Cardiovascular Risk Score (PCE), used in primary care, helps predict the risk of future major eye disease in adults aged 40–79 years.[1][2] A study of 35,909 participants without cardiovascular disease and major eye problems at baseline divided them into four risk groups: low (<5%), borderline (5–7.4%), intermediate (7.5–19.9%), and high (≥20%).[1][2] High-risk participants had a 6.2-fold increased risk of age-related macular disease, a 5.9-fold increased risk of diabetic retinopathy, a 4.5-fold increased risk of hypertensive retinopathy, a 3.4-fold increased risk of retinal vein occlusion, and a 2.3-fold increased risk of glaucoma compared to the low-risk group.[1] These associations remained significant after adjustment for factors such as race, body mass index, kidney disease, and education.[1] The PCE score was particularly accurate in predicting diabetic retinopathy, hypertensive retinopathy, and age-related macular disease.[1][2] The findings were consistent over 5 to 7 years of follow-up.[1][2]