Nutritional disorders and muscle wasting in chronic liver diseases are serious problems that worsen the prognosis of patients and arise as a result of disturbed energy metabolism, increased protein degradation and imbalance of intestinal microflora.[1] Scientists have discovered the concept of the "gut-liver-muscle axis", which explains how gut microbiota, liver metabolism and muscle interact with each other.[1] Intestinal dysbiosis (intestinal microflora imbalance) can promote inflammation of the liver and metabolic disorders, thereby impairing energy utilization in muscles and reducing protein production.[1] These processes eventually lead to malnutrition and sarcopenia (muscle wasting).[1] The article systematically investigates the role of the intestinal microflora in these conditions and clarifies the mechanisms of how the microbiota affects the patient's metabolism and nutritional status through the mentioned intestine-liver-muscle axis.[1] Research also discusses the potential for microbiome-targeted interventions that could improve nutritional outcomes in patients with liver disease.[1]