A large-scale analysis identified 235 circulating metabolites associated with future risk of type 2 diabetes. The study included an integrated analysis of data from 23,634 individuals. The findings revealed potential genetic and environmental factors influencing these metabolites. The results provide a basis for understanding the metabolic landscape underlying type 2 diabetes risk. These findings inform preventive therapies targeting specific metabolic pathways. The study was published in Nature Medicine on January 15, 2026 with DOI: 10.1038/s41591-025-04147-y.