A new study published in the Journal of the American Medical Association revealed that approximately 25% of dementia patients in the Medicare program are receiving potentially inappropriate medications despite longstanding warnings about their safety[1]. These medications include antipsychotics, barbiturates, benzodiazepines, and certain antidepressants, which increase the risk of confusion, falls, and hospitalizations[1]. Researchers analyzed data from 2013 to 2021 and found that although prescriptions fell from 20% to 16%, more than two-thirds of patients receiving these drugs did not have a documented clinical reason for their administration[1]. Patients with cognitive impairment receive these risky drugs more often than persons with normal cognitive status[1]. Drugs that affect dopamine, serotonin, GABA, or acetylcholine can make vulnerable patients confused, worsen gait instability, and cause other adverse effects[2]. The study highlights the need to improve the quality and safety of care for millions of older Americans.