Facing significant funding cuts through 2025, the global health community is at a crossroads.[1] These cuts have serious consequences, but they also offer an unprecedented chance to address the well-known shortcomings of the current system.[1] A crisis creates a sense of urgency that enables systemic change.[1] The authors of the commentary emphasize the need for four paradigm shifts to create an agenda for global healthcare reforms.[2] Stabilization of the system and its transformation should take place simultaneously in tandem.[1] The article was published in The Lancet on January 16, 2026.[2]