Extramammary Paget's disease of the scrotum is a rare skin cancer that occurs in areas with apocrine glands[10]. The case describes a patient with erythema on the root of the left penis and scrotum that lasted for more than 6 months, and histopathological examination confirmed the diagnosis of extramammary Paget's disease[1]. The initial clinical symptoms of this disease resemble chronic dermatoses, which can make early diagnosis difficult[1]. It is crucial to rule out metastatic disease or underlying internal malignancies[1]. The patient underwent wide local excision under general anesthesia with negative surgical margins[1]. Due to the diffuse nature of the lesion boundaries, he was given postoperative adjuvant radiotherapy[1]. The patient tolerated the treatment well and is on a planned follow-up regimen without evidence of recurrence[1].