The study analyzed data from the FAERS database from January 2004 to December 2024 and identified the risk of drug-induced cataracts using disproportionality analysis with measures of ROR, PRR, BCPNN, and MGPS. There were 671 drugs reported to be associated with cataracts in the database, with the analysis highlighting 64 drugs with significant risk. The most risky were omidenepag isopropyl (BCPNN 7.69), clobazam (7.36) and nitisinone (6.02), mainly from the therapeutic classes of hormonal, oncological, ophthalmological and nervous system drugs. Ophthalmic drugs had the shortest average time to cataract onset – 120.29 days. Affected were mainly women (67.59%) and older people with an average age of 63.85 ± 14.54 years. The study provides evidence for preventive strategies and clinical decision-making.