Here is a brief, factual summary of the article in Slovak: The article deals with therapies for Clostridioides difficile infection (CDI) in high-risk patients with recurrent cases. CDI is a serious infection that often recurs, especially in elderly and debilitated patients. The article describes various therapeutic approaches such as faecal transplantation, new antibiotics and innovative treatment methods that are used to treat these challenging cases. The aim is to provide an overview of the latest trends and procedures in the management of recurrent CDI in high-risk patients.