A meta-analysis included 13 studies with a total of 1,209,263 patients and found that diabetes mellitus (DM) is associated with an increased risk of death in patients with sepsis—specifically, a 1.25-fold increase in risk[3]. The risk was even higher for in-hospital mortality, where the risk increased to 1.60-fold[3]. Analyzes by country showed the most significant effects in China (1.79-fold increase), Israel (1.81-fold) and the Netherlands (1.14-fold)[3]. Studies using Sepsa-3 criteria have shown a significant increase in risk to 1.59-fold[3]. The authors explain these findings by pathophysiological mechanisms including immune dysfunction, dysregulated inflammatory responses and the presence of chronic comorbidities[3]. The strength of association between DM and mortality varied by country, study design, and sepsis diagnostic criteria, suggesting heterogeneity among existing studies[3].