A retrospective study analyzed 499 patients with ischemic stroke, of which 434 in the anterior circulation (AC) and 65 in the posterior circulation (PC). AC events had significantly higher C-reactive protein (14.97 vs. 8.65 mg/L, p < 0.001), while PC events were dominated by higher white blood cell counts (10.80 vs. 9.36 × 10^9/L, p < 0.001). PC events showed a lower baseline NIHSS score (8.31 vs. 13.47, p < 0.001). Patients with PC events were older and more often had a previous stroke, while AC events were associated with atrial fibrillation. The study shows different inflammatory profiles and clinical severity between AC and PC events. These differences support classification as separate pathophysiological entities for the development of specific therapies.