Proton pump inhibitors are among the most widely used drugs worldwide, but due to their widespread use, it is important to understand their potential adverse effects[1]. Although long-term adverse effects have received considerable attention, there is uncertainty about the causality of many of them[1]. One of the frequently mentioned concerns is the increased risk of gastric cancer, however the existing studies had major methodological limitations[1]. Excessive use of proton pump inhibitors, especially long-term use without a clear indication, is a recognized problem[1]. Low-quality evidence that falsely suggests that a useful drug is harmful could discourage its rational use when indicated and appropriate[1]. Researchers conducted an international population-based case-control study to assess the association between proton pump inhibitor use for more than one year and health risks[1].