The study compared the tilt and decentration of intraocular lenses (IOLs) with a plate haptic design (group A: 37 patients, ATTORBI 709 M) and a C-loop design (group B: 42 patients, PY-60 AD) one month after cataract surgery. They performed the examinations using SS-OCT and a customized CNN algorithm with a corneal apex reference. A total of 79 patients (79 eyes) were included, before surgery there were no statistically significant differences in eye parameters between the groups (all p > 0.05). Decentralization was significantly less in group A (0.16 ± 0.08 mm) versus group B (0.42 ± 0.28 mm, p < 0.001), whereas tilt was not different (group A: 4.60 ± 1.27°; group B: 4.63 ± 1.93°, p = 0.948). Both groups showed a predominant inferotemporal tilt of the crystalline lens and IOL, the decentration did not have a distinct distribution pattern. Multivariate linear regression confirmed a correlation between IOL tilt and crystalline lens tilt in both groups (p < 0.003). The plate haptic IOL design exhibits less decentration than the C-loop design. Clinicians should consider this difference in stability when choosing an IOL.