A meta-analysis of 19 studies with 1,775 patients examined the effectiveness of combined treatment of hypertrophic scars using a fractional CO₂ laser and triamcinolone acetonide injection. Compared with triamcinolone acetonide injection alone, this combination significantly improved scar status—reducing the Vancouver Scar Score by 2.52 points, reducing pruritus by 0.86 points, and pain by 1.04 points. The combination also significantly reduced scar thickness and blood levels of inflammatory markers (DGFβ, VEGF and TNF-α). In terms of safety, the combined treatment reduced the incidence of skin atrophy compared to the injection alone. There were no significant differences between the two groups in adverse effects such as folliculitis, erythematous edema, allergic reactions or pigmentation. However, the authors caution that all studies were conducted in China with Chinese patients, so further research in other populations is needed to confirm these results.