The editorial compares the D-dimer test to wine, which has matured over time into an indispensable tool for outpatients with symptoms of venous thromboembolism. The ADJUSTED-DVT trial examines age-adjusted D-dimer thresholds in patients with a low to moderate probability of deep vein thrombosis. In patients 75 years of age or older, the use of an age-adjusted cutoff increased negative D-dimer results from 33 to 99 of 379 cases, or from 8.7% to 26.1%. This improved the sensitivity of the test instead of the standard cutoff of 500 μg/L. The article also mentions the benefits of statins in people with low cardiovascular risk, where the decision to use them depends on the expected benefit.