Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors

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Source: Science Magazine

Original: https://www.science.org/doi/abs/10.1126/science.adu2896?af=R...

Published: 2026-01-22T08:00:00Z

Researchers at Johns Hopkins Medicine have discovered that oligodendrocyte progenitor cells in the brain are constantly trying to create new myelin-producing cells[1]. Myelin is a protective covering of nerve fibers, which is important for the proper functioning of the nervous system[4]. Research published in the journal Science shows that myelin repair occurs through constitutive differentiation, meaning that this process occurs continuously and not just in response to damage[1][3]. Scientists have observed that when progenitor cells attempt to differentiate, they form dandelion-like structures they call DACS[6]. This discovery changes the current understanding of myelin repair, as previous models assumed that progenitor cells begin to differentiate only in response to changes in neural activity[3]. The findings may have important implications for the development of new therapies to treat diseases associated with myelin damage, such as multiple sclerosis[5].