The article describes a couple-close approach to the synthesis of semi-saturated cyclic structures that improve solubility, affinity to target molecules and specificity compared to fully aromatic systems[1][2][3]. Until now, these structures have been prepared by laborious, non-modular syntheses, which reduced the throughput and chemical diversity in hit-to-lead campaigns[1][2][3]. The new method uses a dual radical mechanism: nickel-catalyzed metallaphotoredox C(sp²)-C(sp³) cross-coupling of heteroaryl halides with bifunctional feedstocks, followed by intramolecular Minisci-type radical cyclization[1][2][3]. Intermediates such as bromoalkylpyridines are cyclized in one bath with tris(trimethylsilyl)silane, ZnCl₂ and oxygen under a photoreactor[1]. The approach allows the synthesis of various spirocyclic, bridged and substituted saturated rings from commercially available haloheterocyclic compounds and bromoalcohols or diols[1][2][3]. The method is regioselective, stereospecific and suitable for late-stage functionalization of pharmaceutical structures, including previously unavailable systems[1][2][3].