The Centers for Disease Control and Prevention (CDC) has released changes to the 2025 immunization schedule for children, adolescents, and adults[1][2][3]. The changes include new and updated recommendations for vaccines against COVID-19, influenza, meningococcal serotype B, pneumococcal conjugate vaccines (PCV), and respiratory syncytial virus (RSV)[1][2][3]. It is recommended to lower the age limit for pneumococcal vaccination from 65 to 50 years[1][2]. For adults older than 65 years, a second dose of the COVID-19 vaccine is recommended for 2024-2025 with a minimum interval of two months[1][2]. People aged 6 months to 64 years with mild or severe immunosuppression can receive a second dose of the vaccine against COVID-19 and, conditionally, a third dose based on a joint decision with a doctor[1][2]. Updated vaccination protocols are available on the CDC website and reflect the recommendations of the Advisory Committee on Immunization Practices (ACIP)[1][3][4].