A prospective cohort study followed 324 women in Turkey 6 weeks postpartum to determine whether maternal blues (MB) predicts postpartum depression (PPD) independently of psychosocial factors. MB status was assessed in the first week after delivery and PPD risk after 4–6 weeks using the Edinburgh Postnatal Depression Scale (EPDS, threshold ≥12). Of the 324 women, 84 (25.9%) were at high risk for PPD. After propensity score matching (PSM) analysis on the matched cohort (n=168), multivariate logistic regression showed MB as a significant predictor (aOR=3.52, 95% CI: 1.98–6.24, p<0.001). Marital dissatisfaction was a stronger independent predictor (aOR=5.98, 95% CI: 2.95–12.14, p<0.001). The accuracy of MB for predicting PPD is moderate (AUC=0.62). The study recommends screening with the integration of psychosocial risk factors, including MB.