The article describes the Popeye sign in transthyretin amyloidosis. This is a clinical symptom that occurs in connection with this disease. It was published in the New England Journal of Medicine, Volume 394, Number 3, Page 310, on January 15, 2026. The author is Giuseppe Famularo. The DOI of the article is 10.1056/NEJMc2514537.[1] Transthyretin amyloidosis is caused by an unstable transthyretin protein that misfolds into amyloid.[2] Symptoms include muscle weakness, cardiomyopathy, and polyneuropathy.[2] The article does not report specific statistics or study results.