A study investigated the effect of Guipiheji mixture combined with ferrous succinate tablets to improve iron deficiency anemia (IDA) in 80 patients. Patients were divided into an observation group (n=40, Guipiheji + ferrous succinate) and a control group (n=40, only ferrous succinate). After treatment, the levels of hemoglobin (Hb), hematocrit (HCT), red blood cell count (RBC), mean corpuscular volume (MCV), serum iron (SI), iron saturation and T-cells CD3+, CD4+, CD8+ increased significantly in both groups (P < 0.05), while the observed group had higher values than the control. Total iron binding capacity (TIBC) levels decreased in both groups, with significantly lower values in the observation group (P < 0.05). The effective rate was higher in the observation group (P < 0.05). Univariate logistic regression showed an association with treatment response of anemia severity (OR = 3.595, 95% CI: 1.139–11.350, P = 0.029) and pretreatment Hb (OR = 0.933, 95% CI: 0.874–0.903). After multivariate adjustment, no variable had an independent predictive value (P > 0.05). The study did not control for confounding factors such as comorbidities, diet, or menstrual blood loss.[1]