Septic shock is a life-threatening condition that often leads to multiple organ failure despite standard treatment[1]. In this case, a 64-year-old woman with septic shock probably caused by a urinary tract infection developed lung, kidney, liver failure and a drop in blood cell count[1]. Initial treatment, including fluids, broad-spectrum antibiotics, corticosteroids, and noninvasive ventilation, was inadequate[1]. The patient had significantly increased inflammatory markers (IL-6: 47,089 pg./mL) and serious metabolic disorders[1]. Therefore, doctors introduced continuous veno-venous hemofiltration with hemoadsorption, which led to a rapid reduction of inflammatory markers and stabilization of blood circulation[1]. Subsequently, combined additional support was used, including hemoadsorption devices, plasma exchange and other techniques, with two separate extracorporeal circuits running at the same time[1]. Despite progressive respiratory failure requiring invasive ventilation and tracheostomy, the patient eventually recovered with recovery of liver and kidney function and successful weaning from ventilation[1].