The diagnosis dilemma of coexistence of neurosarcoidosis and tuberculosis: case reports and literature review

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Source: Frontiers Medicine

Original: https://www.frontiersin.org/articles/10.3389/fmed.2026.1709977...

Published: 2026-01-30T00:00:00Z

Sarcoidosis is a multisystem disease characterized by non-caseous epithelioid granulomas. Its neurological form, neurosarcoidosis, affects the central or peripheral nervous system and presents a diagnostic challenge. Sarcoidosis and tuberculosis have significant clinicopathological overlap and may rarely coexist. The study describes three patients with neurosarcoidosis: two with central nervous system involvement and one with peripheral involvement. Two patients had confirmed active tuberculosis and one had latent tuberculosis infection. FDG PET helps detect extraneural foci of sarcoidosis and determine biopsy sites. Before treating sarcoidosis, a thorough screening for tuberculosis is essential. The coexistence of these conditions brings diagnostic and therapeutic problems.