A new analysis published in Nature Medicine found no link between paracetamol use during pregnancy and autism in children.[1] The study used a novel approach to control for genetic and environmental factors through a review and meta-analysis.[1] When comparing siblings exposed and not exposed to paracetamol in utero, researchers found no differences in the risk of autism, ADHD, or mental retardation.[1][2] This is the largest epidemiological analysis of this topic to date, following children for up to 26 years.[1] There was a slight increase in the incidence of these disorders in the whole population, but paracetamol did not contribute to this.[1] Previous studies from 2021 warned of a possible risk, but sibling comparisons did not confirm this.[1][2] Paracetamol remains a safe choice for the treatment of pain and fever in pregnancy at the lowest effective dose and for the shortest duration.[1][2]