According to the law of mass action, all adverse drug reactions are related to the concentration of the drug at the site of action and thus to the administered dose. There are therefore no dose-independent adverse reactions. The DoTS classification (dose, time, sensitivity) divides adverse drug reactions into three types according to the relationship to dose or concentration. Hypersusceptible reactions occur at lower than therapeutic doses or concentrations; include all allergic reactions and some non-allergic, such as angioedema associated with ACE inhibitors. Adverse reactions are related to doses or concentrations to the same extent as those associated with therapeutic benefit. The article discusses the use of artificial intelligence to predict and detect these adverse drug reactions.