The MASAI trial compared AI-assisted mammography screening with standard double-reading without AI in a randomized, controlled, non-inferiority, single-blind, population-based accuracy screening trial.[1] AI-assisted screening showed a non-inferior frequency of interval cancers and a smaller number of interval cancers with unfavorable characteristics.[1] The sensitivity was higher, the specificity the same as with the standard procedure.[1] Cancer detection increased by 29% (6.4 versus 5.0 per 1,000 screened), while maintaining a similar false-positive rate.[1][2] The workload of radiologists decreased by 44%.[1][2] AI has contributed to the detection of small invasive cancers without lymphatic involvement, including triple-negative forms.[1] Findings suggest that AI can improve screening performance and reduce reading burden.[1]