Case Report: Conservative management of herpes simplex keratitis with corneal perforation and anterior chamber collapse

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Source: Frontiers Medicine

Original: https://www.frontiersin.org/articles/10.3389/fmed.2026.1749225...

Published: 2026-02-02T00:00:00Z

In a 54-year-old man with recurrent redness and pain in the left eye, examination revealed central corneal infiltrates, a positive Seidel test, and anterior chamber collapse. A PCR test from the collected tear sample confirmed infection with the herpes simplex virus. Treatment included oral valacyclovir, topical ofloxacin ointment, and 0.1% fluorometholone eye drops. After one month, visual acuity improved from counting fingers at 80 cm to 20/30. The corneal lesions healed and the anterior chamber reformed. Conservative treatment was successful without surgery. The case highlights the importance of accurate diagnosis and clinical monitoring in HSK with corneal perforation and anterior chamber collapse.