Researchers have discovered that Reelin protein can help heal leaky gut and alleviate symptoms of depression.[1][2][3] Chronic stress reduces levels of Reelin in the gut of preclinical models, which weakens the protective lining of the gut and allows harmful bacteria and toxins to enter the bloodstream, triggering inflammation and worsening depression.[1][2][3][5] A single intravenous injection of 3 µg of Reelin restored protein levels, promoted gut lining regeneration, and produced antidepressant effects.[1][4][5] The healthy intestinal lining is renewed every 4 to 5 days, with Reelin promoting epithelial cell renewal.[1][2] About 70% of people with depressive episodes have concomitant gastrointestinal problems that increase the severity of symptoms.[5] A study published in the journal Chronic Stress suggests a role for Reelin in the gut-brain axis in psychiatric disorders.[4][5] The research was supported by the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC).[1][3]