Editorial: Nanomedicine targeting central nervous system

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Source: Frontiers Medicine

Original: https://www.frontiersin.org/articles/10.3389/fmed.2026.1755137...

Published: 2026-02-03T00:00:00Z

Nanomedicine focuses on the use of nanoparticles for the targeted transport of drugs to the central nervous system (CNS). Studies in rodents have shown that nanoparticles can bypass the blood-brain barrier by transporting drugs such as risperidone through the olfactory nerves directly into the CNS[1]. Intranasal vaccination with nanoparticles expressing pneumococcal surface antigens is another possibility[1]. The use of nano-carriers for targeted gene therapy through the foramen rotundum to the scala tympani is promising[1]. Liposomal and polymerosomal nanoparticles serve for the targeted transport of drugs when injected into the foramen rotundum[1]. Nanoparticles enable diagnosis, therapy, including chemotherapy and radiotherapy, with organ- or cell-specific delivery[2][3]. These systems reduce side effects and promote individualized treatment[3].