The study analyzed the deviation of clinical research coordinators (CRCs) from their assigned responsibilities in Sichuan, China through a questionnaire distributed online to 202 stakeholders, including institutional staff, sponsors, and SMOs. The questionnaire had high reliability (Cronbach's alpha > 0.7) and validity (S-CVI/UA and S-CVI/Ave > 0.9). According to 177 respondents (87.62%), the main reason for exceeding the tasks was a unclear understanding of the CRC's duties, while 181 respondents (89.60%) mentioned frequent requests by investigators for unauthorized tasks. The most frequent transgression (152 respondents, 75.25%) was the use of medical accounts to edit medical records in hospital systems. 187 participants (87.62%) suggested banning the sharing of login data and strengthening the management of investigators as a measure. Chi-square test did not show statistically significant differences between subgroups (p > 0.05). The conclusion highlights the lack of awareness among investigators of GCP and the need for strict adherence to CRC roles for trial quality.