On December 4, 2025, the Department of Health and Human Services (HHS) released a strategy for integrating artificial intelligence (AI) into its internal operations, scientific research, and public health programs.[3][2] This strategy supports the Trump administration's AI plan and the January 23, 2025 executive order to remove barriers to AI innovation.[3][1] The strategy focuses on five pillars: ensuring governance and risk management for public trust, designing infrastructure and platforms according to user needs, developing the workforce and reducing administrative burdens, supporting health research and reproducibility, as well as modernizing care delivery and public health for better outcomes.[3] HHS is implementing a centralized "OneHHS" approach to speed decision-making and eliminate information silos.[1] Each division must identify high-impact AI systems that affect health outcomes, rights, or sensitive data and implement minimum risk management measures including bias mitigation, outcome monitoring, security, and human oversight by April 3, 2026.[2] If the AI tool does not meet the requirements, it must be stopped or phased out.[2] HHS will maintain a publicly available inventory of AI use cases and a standard taxonomy to share best practices.[1]