The mpox epidemic is not over, although global concern is waning, but outbreaks, disease and death continue in Africa and around the world[1]. An outbreak of mpox in 2022 generated worldwide attention, but the epidemic persists[1]. The authors highlight the ongoing mpox epidemics in Africa and the world[1]. There is a disproportionate burden in Africa, particularly in the Democratic Republic of the Congo, which accounted for 96% of the continent's more than 26,000 cases in 2024[1][3][7]. The World Health Organization declared the epidemic a public health emergency of international concern in August 2024[1][4][5]. Ending transmission requires a sustained global response that goes beyond reactive measures[1].