Mother and child health 4.5 years after gestational diabetes mellitus managed using tight or less tight targets for glycaemic control: Post-hoc follow-up study of the TARGET trial

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Source: PLOS Medicine

Original: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004635...

Published: 2026-02-03T14:00:00Z

The TARGET study compared the health of mothers and children 4.5 years after gestational diabetes, which was controlled with either strict or less strict targets for blood sugar control during pregnancy. The research involved 315 mothers and 313 babies from 10 hospitals in New Zealand who were followed from October 2020 to June 2022. The mothers' glycated hemoglobin (HbA1c) levels and the babies' body mass indexes were similar in both groups, with the babies in the strict target group only 0.8cm higher. Surprisingly, children in the group with strict glycemic targets performed worse in motor function - 28.4% had coordination difficulties compared to 17.8% in the group with less strict targets. There were also more children with suspected autism spectrum disorders (2.6% vs. 0%) and higher total difficulty scores in the strict goal group. The study concluded that strict compared with less strict glycemic targets in women with gestational diabetes during pregnancy did not lead to better maternal or child health outcomes and may be associated with adverse motor and behavioral outcomes.