'Time Is Brain' Again, Now for Hemostatic Control of Intracerebral Bleeds

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Source: MedPage Today

Original: https://www.medpagetoday.com/meetingcoverage/isc/119746...

Published: Wed, 04 Feb 2026 17:42:48 -0500

There is still hope that recombinant factor VIIa (rFVIIa) may be an effective hemostatic treatment for acute intracerebral hemorrhage (ICH) under the right conditions.[1] The slogan "time is brain" applies again, this time to control bleeding in the brain.[1] rFVIIa showed promise in a phase 2b clinical trial, where a dose of 80 μg/kg administered within 4 hours of symptom onset led to positive results.[1] However, the fastest administration of the drug is not optimal.[1] Treatment of intracerebral hemorrhage also includes timely reduction of elevated blood pressure.[1][3] In 38% of patients with hypertensive ICH examined within 3 hours of onset, CT showed significant bleeding progression.[1] The ATACH and INTERACT studies confirmed that a rapid reduction in pressure in the first hours reduces the growth of the hematoma.[1]