The study evaluated the efficacy and safety of carbon dioxide laser-assisted deep sclerectomy (CLASS) in six patients (six eyes) with medically refractory Posner-Schlossman syndrome (PSS) over 18 months. Preoperative mean intraocular pressure (IOP) was 28.30 ± 5.16 mmHg, after surgery it decreased to 14.56 ± 1.82 mmHg at the last follow-up. Visual acuity recovered to or exceeded preoperative levels in all patients. Retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness did not change significantly compared to preoperative values at 6, 12, and 18 months. Field of view parameters (MD, PSD) remained stable. Complications included transient hypotony (three eyes), peripheral anterior synechiae (two eyes, treated with laser), transient shallow anterior chamber (one eye), and mild anterior chamber reaction (one eye), all managed conservatively without sequelae. CLASS provided effective IOP reduction while preserving the structural and functional integrity of the optic nerve.