The article, Asia-Pacific perspectives on global health architecture reform, was published in Nature Medicine online on February 4, 2026 with doi:10.1038/s41591-025-04180-x. Designing an appropriate global health architecture requires regional coordination and global alignment. It presents a Pacific women's perspective on global health with respect to the history of colonialism and exclusion of indigenous Pacific peoples. It proposes a rethinking of global health through four areas: sovereignty, integration of worldviews, connectivity and equity with participation. It emphasizes the need to shift from the dominant Western worldview to pluralistic perspectives including indigenous Pacific knowledge. An example is the Healthy Islands vision from the Yanuca Island Declaration (1995), which prioritizes children's health, a healthy environment, dignified aging, ecological balance and ocean protection. It calls for the strengthening of health systems, research and policies led by the Pacific region with long-term peer-to-peer collaborations.[1]