New results from randomized trials showed that a ketogenic diet added to drug therapy had antidepressant effects in patients with treatment-resistant depression. The primary endpoint was severity of depression at 6 weeks, measured using standardized instruments. The study focused on patients who did not respond to conventional anti-depressant medications. The ketogenic diet led to a significant improvement in depression symptoms compared to standard treatment. The results indicate the potential of the keto diet as an adjunctive therapy in difficult-to-treat depression. The study was published in MedPage Today and highlights the need for more research.