A large study analyzing data from approximately 155,000 people from 23 randomized clinical trials found that statins caused only a 7% relative increase in muscle pain or weakness compared to placebo.[1] Statin therapy is not the cause of muscle pain in 9 out of 10 people who experience these symptoms while taking the drug.[1] The finding suggests that only about one in 15 patient reports of muscle problems is actually caused by statins.[1] Side effects such as myalgia or myopathy were mild and led to treatment discontinuation in only 1.1% of patients.[2] Reintroduction of a statin after discontinuation showed a significantly shorter time to symptom recurrence (median 2 weeks) compared to first onset (median 14 weeks), supporting causality between statin use and muscle manifestations in those susceptible.[2] Although muscle symptoms have been associated with statins, most people do not experience them, and the treatment is generally safe.[1][3]