The article provides an overview of pharmaceutical advertising on Super Bow. Hims & Hers aired the "Sick of the System" commercial during the third quarter of Super Bowl LIX, which was watched by 127.7 million viewers according to FOX Sports[1]. The ad showed junk food, belly fat, obesity risk statistics, and big pharmaceutical companies' high prices, while promoting their weight loss products, including compressed GLP-1 drugs, as an alternative to expensive brand name drugs like Ozempic and Wegovy[1]. Novo Nordisk responded with its own "Check Before You Inject" advertisement, which warned of the dangers of compressed semaglutide, such as impurities, banned substances, or incorrect dosages, and emphasized that only Weg and Ozempic are FDA-approved[1]. Ro aired the first Super Bowl commercial with Serena Williams for the "Healthier on Ro" campaign during Super Bowl LX 2026[2][3][4][5][6]. In it, Serena Williams reported that she lost 34 pounds in a year on GLP-1 drugs, reduced stress on her joints, and stabilized her blood sugar[2][3]. The campaign highlights the health benefits of GLP-1 drugs, including weight loss and other biomarkers, with support for FDA-approved options[2][3].