Right C7 neurotomy at the intervertebral foramen plus intensive speech and language therapy versus intensive speech and language therapy alone for chronic post-stroke aphasia: multicentre, randomised controlled trial

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Source: BMJ

Original: http://www.bmj.com/content/392/bmj.s231.short?rss=1...

Published: 2026-02-05T04:42:31-08:00

The study compared right C7 intervertebral foramen neurotomy plus intensive speech and language therapy (iSLT) with iSLT alone in patients with chronic aphasia after stroke. It was a multicenter, randomized, investigator-blinded, controlled trial with 50 patients (25 in each group), conducted from July 25, 2022 to July 31, 2023.[2] The primary outcome was change in Boston Naming Test (BNT, range 0-60) score from baseline to one month.[2] In the intervention group, the average increase in BNT was 11.16 points, in the control group it was 2.72 points (difference 8.51 points, 95% CI 5.31 to 11.71, P<0.001); the difference remained stable at six months (8.26 points, 4.16 to 12.35, P<0.001).[2] The aphatic quotient improved significantly more in the intervention group (difference at one month 7.06 points, 4.41 to 9.72, P<0.001).[2] Activities of daily living and post-stroke depression also improved in patients in the intervention group versus controls.[2] No treatment-related serious adverse events were reported at six months.[2]