DNA origami vaccines program antigen-targeting germinal centers.[1][3] Their main goal is to activate rare subdominant progenitor B cells in germinal centers (GCs) to produce broadly neutralizing antibodies (bnAbs) against HIV.[1][3] The researchers designed DNA origami viral particles (DNA-VLPs) with 30 equally spaced copies of the immunogen eOD-GT8, which targets the germline HIV Env protein.[1][3][4] These particles do not elicit a scaffolding-specific response, thus minimizing off-target B cells.[1][3] Compared to the advanced protein nanoplast, they significantly increased the expansion of epitope-specific GC B cells and bnAb-linear progenitors in humanized mice after a single immunization.[1][3] DNA-VLPs thus support targeted germinal centers on the target antigen and represent a promising vaccination platform.[1][3]