Article: An article from JAMA Network reports on the latest research and debate in medicine and public health. The OPTION RCT study investigated the use of tenecteplase in patients with ischemic stroke in the time window 4.5 to 24 hours after the event, specifically non-large vessel occlusion. Other articles cover topics such as systemic hormone therapy for breast cancer patients, the misuse of nitrous oxide, and building empathy in medicine. The article also provides information on cancer patient survival during the COVID-19 pandemic and risk factors for acral melanoma in US veterans. A new airflow system for critical avalanche backfill is also discussed. Current topics include the management of premenstrual disorders, blood pressure above target in hypertensive adults, and the prevalence of obesity in adults by race and ethnicity.