Scientists have identified a new compound, Mic-628, that reliably advances the body's internal clock. This compound targets a key clock protein and turns on a gene that sets daily rhythms. This synchronizes the master clock in the brain and the clock in the whole body. In mice with simulated jet lag, a single dose almost halved recovery time. Moving the clock forward is notoriously difficult to achieve. Mic-628 is a promising new compound to address shingles.