The study investigated metabolic changes in the serum and urine of patients with liver cirrhosis using an advanced UPLC-QTOF/MS analytical technique.[1] The research team compared the metabolic profiles between 30 healthy subjects and 28 patients with liver cirrhosis.[1] 55 dysregulated metabolites were identified in serum and 51 metabolites in urine.[1] Four metabolites were present in both biofluids – glycoursodeoxycholic acid, urobilin, glycocholic acid and urobilinogen.[1] Analysis revealed three co-regulated metabolic pathways associated with cirrhosis: tryptophan metabolism, glycerophospholipid metabolism, and porphyrin metabolism.[1] These shared biomarkers and metabolic pathways offer a non-invasive way to clinically detect liver cirrhosis without the need for biopsy.[1]