This multicenter, randomized, double-blind, controlled trial will compare the effects of intravenous opioid-free anesthesia (OFA) with traditional opioid-based anesthesia (OBA) on the quality of recovery after gynecological laparoscopic surgery. It includes 300 adult women in five Chinese hospitals, randomized 1:1 to OFA (dexmedetomidine, esketamine, lidocaine) or OBA (sufentanil), stratified by center. All patients receive bilateral blocks of the transversus abdominis plane and propofol-based anesthesia. The primary outcome is the quality of recovery after 24 hours as measured by the QoR-15 questionnaire. Secondary outcomes include postoperative nausea and vomiting, QoR-15 at 48 and 72 hours, pain at rest and with cough, opioid consumption, quality of life, and chronic pain at 3 months. Adverse events such as hypotension, bradycardia or psychiatric effects are monitored during surgery and hospitalization. The analysis will take place according to the modified intention-to-treat principle; registration number ChiCTR2500106392.